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<!DOCTYPE HTML> <html lang="en-US"> <head> <meta charset="UTF-8"/> <title>Extensive-Stage Small Cell Lung Cancer Treatment | TECENTRIQ® (atezolizumab)</title> <meta name="description" content="Find out about TECENTRIQ® (atezolizumab) for the treatment of extensive-stage small cell lung cancer (ES-SCLC). See full safety for more information."/> <meta name="template" content="flexible-page"/> <meta name="viewport" content="width=device-width, initial-scale=1"/> <link rel="canonical" href="https://www.tecentriq.com/sclc.html"/> <meta property="og:site_name" content="tecentriq"/> <meta property="og:type" content="website"/> <meta property="og:locale" content="en_US"/> <meta property="og:title" content="Extensive-Stage Small Cell Lung Cancer Treatment | TECENTRIQ® (atezolizumab)"/> <meta property="og:description" content="Find out about TECENTRIQ® (atezolizumab) for the treatment of extensive-stage small cell lung cancer (ES-SCLC). See full safety for more information."/> <meta property="og:url" content="https://www.tecentriq.com/sclc.html"/> <meta property="og:image" content="https://www.tecentriq.com/content/dam/gene/tecentriq/global/images/tecentriq-logo.genecoreimg.1200.svg"/> <meta property="og:image:type" content="image/svg+xml"/> <meta property="og:image:width" content="605"/> <meta property="og:image:height" content="196"/> <meta property="og:image:alt" content="TECENTRIQ® (atezolizumab) Logo"/> <meta name="twitter:card" content="summary_large_image"/> <meta name="pub_date" content="2025-05-13T20:57:50Z"/> <link rel="icon" type="image/x-icon" href="/content/dam/gene/tecentriq/global/images/tecentriq_favicon.png"/> <link rel="shortcut icon" type="image/x-icon" href="/content/dam/gene/tecentriq/global/images/tecentriq_favicon.png"/> <link href="https://fonts.googleapis.com/css2?family=Open+Sans:ital,wght@0,400;0,700;1,400;1,700&display=swap" rel="stylesheet"/> <script type="text/plain" 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data-adobe-analytics-cmp="{"lnk-22fdf1d3cc":{"destinationTitle":"Important Safety Information","name":"link","location":"masthead","destinationURL":"/sclc/side-effects/important-safety-information.html","type":"internal","key":"lnk","navigationLevel":"2"}}">Important Safety Information</a> </li> </ul> </div> </li> <li class="cmp-masthead__primary-nav__item cmp-masthead__primary-nav__item--dropdown"> <div class="cmp-masthead__primary-nav-dropdown"> <a class="cmp-masthead__primary-nav-item cmp-masthead__primary-nav-dropdown-button" href="#" data-analytics-nav-level="1" role="button" data-analytics="{\"component\":\"navigation\",\"destinationTitle\":\"Results With TECENTRIQ\",\"location\":\"masthead\",\"destinationURL\":\"#\",\"type\":\"state\",\"navigationLevel\":\"1\"}" data-adobe-analytics-id="lnk-abb39199e4" data-adobe-analytics-cmp="{"lnk-abb39199e4":{"destinationTitle":"Results With 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data-adobe-analytics-cmp="{"lnk-f00cfd1d7b":{"destinationTitle":"How TECENTRIQ May Help","name":"link","location":"masthead","destinationURL":"/sclc/results/how-tecentriq-may-help.html","type":"internal","key":"lnk","navigationLevel":"2"}}">How TECENTRIQ May Help</a> </li> </ul> </div> </li> <li class="cmp-masthead__primary-nav__item cmp-masthead__primary-nav__item--dropdown"> <div class="cmp-masthead__primary-nav-dropdown"> <a class="cmp-masthead__primary-nav-item cmp-masthead__primary-nav-dropdown-button" href="#" data-analytics-nav-level="1" role="button" data-analytics="{\"component\":\"navigation\",\"destinationTitle\":\"Starting TECENTRIQ\",\"location\":\"masthead\",\"destinationURL\":\"#\",\"type\":\"state\",\"navigationLevel\":\"1\"}" data-adobe-analytics-id="lnk-227c099c60" data-adobe-analytics-cmp="{"lnk-227c099c60":{"destinationTitle":"Starting TECENTRIQ","name":"link","location":"masthead","destinationURL":"#","type":"state","key":"lnk","navigationLevel":"1"}}"> <span>Starting TECENTRIQ</span> <i class="cmp-masthead__primary-nav-dropdown-button-icon fa" aria-hidden="true"></i> </a> </div> <div class="cmp-masthead__primary-nav-dropdown-content"> <ul class="cmp-masthead__primary-nav-dropdown-list cmp-masthead__primary-nav-dropdown-list--level2"> <li class="cmp-masthead__primary-nav-dropdown-items "> <a data-analytics-nav-level="2" href="/sclc/starting-tecentriq/infusion-process.html" class="cmp-masthead__primary-nav-dropdown-item cmp-masthead__primary-nav-dropdown-item--level2" target="_self" data-analytics="{\"component\":\"navigation\",\"destinationTitle\":\"The Infusion Process\",\"location\":\"masthead\",\"destinationURL\":\"/sclc/starting-tecentriq/infusion-process.html\",\"type\":\"internal\",\"navigationLevel\":\"2\"}" data-adobe-analytics-id="lnk-c7083efb54" data-adobe-analytics-cmp="{"lnk-c7083efb54":{"destinationTitle":"The Infusion 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TECENTRIQ immunotherapy + chemo* may be an option for you.</p> <p><span class="footnote-text">*Chemotherapy=carboplatin + etoposide<br /> </span></p> </div> </div> </div> </div> </div> <div class="container responsivegrid"> <div id="sclc-hero-buttons" class="cmp-container component-row " data-cmp-instance-path="/content/tecentriq/en_us/sclc/jcr:content/root/container/container_copy/hero/heroSectionContent/container_1321584423/container_copy" style="background-size:cover;background-repeat:no-repeat;" data-optimg-srcset='["", "", ""]'> <div class="cmp-container__inner content-container "> <div class="columncontrol"> <div class="cmp-columncontrol component-row cmp-columncontrol--col2_50 cmp-columncontrol--half-padding" data-cmp-instance-path="/content/tecentriq/en_us/sclc/jcr:content/root/container/container_copy/hero/heroSectionContent/container_1321584423/container_copy/columncontrol" data-analytics-component="columncontrol"> <div class="cmp-columncontrol__column" data-mobile-order="1"> 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families, and healthcare providers who participated in the clinical trial that led to the approval of TECENTRIQ as a <a href="/sclc/results/how-tecentriq-may-help.html" data-analytics="{\"component\":\"text\",\"destinationTitle\":\"first treatment for extensive-stage small cell lung cancer\",\"location\":\"body\",\"destinationURL\":\"/sclc/results/how-tecentriq-may-help.html\",\"type\":\"internal\"}" data-adobe-analytics-id="lnk-aa7b4c5321" data-adobe-analytics-cmp="{"lnk-aa7b4c5321":{"destinationTitle":"first treatment for extensive-stage small cell lung cancer","name":"link","location":"body","destinationURL":"/sclc/results/how-tecentriq-may-help.html","type":"internal","key":"lnk"}}">first treatment for extensive-stage small cell lung cancer</a> (ES-SCLC). Thank you for your courage in the fight against cancer.</p> </div> </div> </div> </div> </div> </div> </div> </div> <div class="experiencefragment aem-GridColumn aem-GridColumn--default--12"> <div class="cmp-experiencefragment" data-cmp-instance-path="/conf/tecentriq/settings/wcm/templates/flexible-page/structure/jcr:content/root/experiencefragment_563569203" data-analytics-component="experiencefragment" data-author-path="false" data-inheritance-path="false" data-analytics-location="safetybar"> <div class="xf-content-height"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="container responsivegrid aem-GridColumn aem-GridColumn--default--12"> <div id="bottom-safety" class="cmp-container component-row " data-cmp-instance-path="/content/experience-fragments/gene/tecentriq/en_us/patient/safety-information/safety-bar-sclc/jcr:content/root/container" style="background-size:cover;background-repeat:no-repeat;" data-optimg-srcset='["", "", ""]'> <div class="cmp-container__inner content-container "> <div class="safetybar"> <section class="cmp-safetybar component-row" data-cmp-instance-path="/content/experience-fragments/gene/tecentriq/en_us/patient/safety-information/safety-bar-sclc/jcr:content/root/container/safetybar" data-analytics-component="safetybar" data-adobe-analytics-cmp="{"isi-85e838602d":{"safetyTitle":"Important Safety Information and Indication","safetyPath":"/content/experience-fragments/gene/tecentriq/en_us/patient/safety-information/safety-bar-sclc","name":"isi","key":"isi"}}" data-adobe-analytics-id="isi-85e838602d" data-disable-animation="true" data-disable-initial-state="true" data-display-one-col-mobile="true" data-small-height="200" data-medium-height="180" data-extra-space-between-columns="0" data-extra-space-between-columns-mobile="0"> <div class="cmp-safetybar__sticky-wrapper "> <div class="cmp-safetybar__inner-wrapper"> <div class="cmp-safetybar__header"> <div class="cmp-safetybar__header-inner content-container"> <h2 class="cmp-safetybar__title"> Important Safety Information and Indication </h2> <div class="cmp-safetybar__buttons"> <button class="button-reset cmp-safetybar__button cmp-safetybar__button--expand" aria-controls="safetybar-content" aria-expanded="false" data-analytics-custom-destination-title="isi_expand" data-analytics="{\"component\":\"safetybar\",\"destinationTitle\":\"isi_expand\",\"location\":\"safetybar\",\"state\":\"isi_expand_on_initial\",\"type\":\"state\"}"> <i class="fa fa fa-chevron-up" aria-hidden="true"></i> </button> <button class="button-reset cmp-safetybar__button cmp-safetybar__button--collapse" aria-controls="safetybar-content" aria-expanded="false" data-analytics-custom-destination-title="isi_collapse" data-analytics="{\"component\":\"safetybar\",\"destinationTitle\":\"isi_collapse\",\"location\":\"safetybar\",\"state\":\"isi_collapse_on_initial\",\"type\":\"state\"}"> <i class="fa fa fa-chevron-down" aria-hidden="true"></i> </button> <button class="button-reset cmp-safetybar__button-top cmp-safetybar__button-top-v3" data-analytics-custom-destination-title="isi_backtotop" data-analytics="{\"component\":\"safetybar\",\"destinationTitle\":\"isi_backtotop\",\"location\":\"safetybar\",\"state\":\"isi_backtotop\",\"type\":\"state\"}"> <span class="cmp-safetybar__button-top-text">Back to Top</span> <i class="fa fa fa-chevron-up" aria-hidden="true"></i> </button> </div> </div> </div> <div id="safetybar-content" class="cmp-safetybar__body" role="region"> <div class="cmp-safetybar__content"> <div class="cmp-safetybar__parsys1 two-col_70-30 mobile-stack-right-column-first content-container"> <div class="safetysnippetlist contentfragmentlist section"> <div class="cmp-safetysnippetlist component-row" data-cmp-instance-path="/content/experience-fragments/gene/tecentriq/en_us/patient/safety-information/safety-bar-sclc/jcr:content/root/container/safetybar/safetybarparsys1/safetysnippetlist" data-analytics-component="safetysnippet"> <div class="cmp-safetysnippetlist__snippets cmp-safetysnippetlist__snippets--first"> <div class="cmp-safetysnippetlist__item" id="PAT_001_indication"> <div class="cmp-safetysnippetlist__item-richtext"> <h5>Indication</h5> <p><b>What is TECENTRIQ?</b></p> <p>TECENTRIQ is a prescription medicine used to treat:</p> <p><b>Adults with a type of lung cancer called small cell lung cancer (SCLC). TECENTRIQ may be used with the chemotherapy medicines carboplatin and etoposide as your first treatment when your lung cancer:</b></p> <ul> <li>is a type called “extensive-stage small cell lung cancer,” which means that it has spread or grown.</li> </ul> <p>It is not known if TECENTRIQ is safe and effective in children when used:</p> <ul> <li>In children for the treatment of SCLC.</li> </ul> </div> </div> </div> <div class="cmp-safetysnippetlist__snippets cmp-safetysnippetlist__snippets--remaining"> <div class="cmp-safetysnippetlist__item" id="PAT_002_long_safety"> <div class="cmp-safetysnippetlist__item-richtext"> <p><b style="font-size: 16.0px;">What is the most important information about TECENTRIQ?<br /> </b>TECENTRIQ can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during your treatment or even after your treatment has ended.</p> <p><b>Call or see your healthcare provider right away if you develop any new or worse signs or symptoms, including:</b></p> <p><b>Lung problems</b></p> <ul> <li>cough</li> <li>shortness of breath</li> <li>chest pain</li> </ul> <p><b>Intestinal problems</b></p> <ul> <li>diarrhea (loose stools) or more frequent bowel movements than usual</li> <li>stools that are black, tarry, sticky, or have blood or mucus</li> <li>severe stomach-area (abdomen) pain or tenderness</li> </ul> <p><b>Liver problems</b></p> <ul> <li>yellowing of your skin or the whites of your eyes</li> <li>severe nausea or vomiting</li> <li>pain on the right side of your stomach area (abdomen)</li> <li>dark urine (tea colored)</li> <li>bleeding or bruising more easily than normal</li> </ul> <p><b>Hormone gland problems</b></p> <ul> <li>headaches that will not go away or unusual headaches </li> <li>eye sensitivity to light </li> <li>eye problems </li> <li>rapid heartbeat </li> <li>increased sweating </li> <li>extreme tiredness </li> <li>weight gain or weight loss </li> <li>feeling more hungry or thirsty than usual</li> <li>urinating more often than usual </li> <li>hair loss </li> <li>feeling cold </li> <li>constipation </li> <li>your voice gets deeper </li> <li>dizziness or fainting </li> <li>changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness</li> </ul> <p><b>Kidney problems</b></p> <ul> <li>decrease in your amount of urine </li> <li>blood in your urine</li> <li>swelling of your ankles </li> <li>loss of appetite</li> </ul> <p><b>Skin problems</b></p> <ul> <li>rash </li> <li>itching </li> <li>skin blistering or peeling</li> <li>painful sores or ulcers in mouth or nose, throat, or genital area </li> <li>fever or flu-like symptoms </li> <li>swollen lymph nodes</li> </ul> <p><b>Problems can also happen in other organs.<br /> These are not all of the signs and symptoms of immune system problems that can happen with TECENTRIQ. Call or see your healthcare provider right away for any new or worse signs or symptoms, including:</b></p> <ul> <li>Chest pain, irregular heartbeat, shortness of breath, or swelling of ankles</li> <li>Confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs</li> <li>Double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight</li> <li>Persistent or severe muscle pain or weakness, muscle cramps<br /> </li> <li>Low red blood cells, bruising</li> </ul> <p><b>Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include:</b></p> <ul> <li>chills or shaking </li> <li>itching or rash </li> <li>flushing </li> <li>shortness of breath or wheezing</li> <li>dizziness </li> <li>feeling like passing out </li> <li>fever </li> <li>back or neck pain</li> </ul> <p><b>Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic)</b>. These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with TECENTRIQ. Your healthcare provider will monitor you for these complications.</p> <p><b>Getting medical treatment right away may help keep these problems from becoming more serious.</b> Your healthcare provider will check you for these problems during your treatment with TECENTRIQ. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with TECENTRIQ if you have severe side effects.</p> <p><b>Before you receive TECENTRIQ, tell your healthcare provider about all of your medical conditions, including if you:</b></p> <ul> <li>have immune system problems such as Crohn’s disease, ulcerative colitis, or lupus</li> <li>have received an organ transplant</li> <li>have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)</li> <li>have received radiation treatment to your chest area</li> <li>have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome</li> <li>are pregnant or plan to become pregnant. TECENTRIQ can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with TECENTRIQ. <b>Females who are able to become pregnant:</b><ul> <li>Your healthcare provider should do a pregnancy test before you start treatment with TECENTRIQ.</li> <li>You should use an effective method of birth control during your treatment and for at least 5 months after the last dose of TECENTRIQ.</li> </ul> </li> <li>are breastfeeding or plan to breastfeed. It is not known if TECENTRIQ passes into your breast milk. Do not breastfeed during treatment and for at least 5 months after the last dose of TECENTRIQ.</li> </ul> <p><b>Tell your healthcare provider about all the medicines you take,</b> including prescription and over-the-counter medicines, vitamins, and herbal supplements.</p> <p><b>The most common side effects of TECENTRIQ when used in lung cancer with other anti-cancer medicines include:</b></p> <ul> <li>feeling tired or weak</li> <li>nausea</li> <li>hair loss</li> <li>constipation</li> <li>diarrhea</li> <li>decreased appetite</li> </ul> <p>TECENTRIQ may cause fertility problems in females, which may affect the ability to have children. Talk to your healthcare provider if you have concerns about fertility.</p> <p>These are not all the possible side effects of TECENTRIQ. Ask your healthcare provider or pharmacist for more information about the benefits and side effects of TECENTRIQ.</p> <p>You may report side effects to the FDA at <a href="tel:18003321088" data-analytics="{\"component\":\"safetysnippet\",\"destinationTitle\":\"1-800-FDA-1088\",\"location\":\"safetybar\",\"destinationURL\":\"tel:18003321088\",\"type\":\"external\"}" data-adobe-analytics-id="lnk-13ce3a47d0" data-adobe-analytics-cmp="{"lnk-13ce3a47d0":{"destinationTitle":"1-800-FDA-1088","name":"link","location":"safetybar","destinationURL":"tel:18003321088","type":"external","key":"lnk"}}">1-800-FDA-1088</a> or <a href="http://www.fda.gov/medwatch" target="_blank" data-analytics="{\"component\":\"safetysnippet\",\"destinationTitle\":\"www.fda.gov/medwatch\",\"location\":\"safetybar\",\"destinationURL\":\"http://www.fda.gov/medwatch\",\"type\":\"external\"}" data-adobe-analytics-id="lnk-f625cc9fa6" 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